VCAM1 anticorps

N° du produit ABIN2688881

Cet anticorps Rat Monoclonal détecte spécifiquement VCAM1 dans FACS, IP, IF, IHC (fro) et BR. Il présente une réactivité envers Souris et a été mentionné dans 7+ publications.

Aperçu rapide pour VCAM1 anticorps (ABIN2688881)

Antigène: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp VCAM1 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR)

Clone: 429

Détail du produit anti-VCAM1 anticorps

Marque: BD Pharmingen™

Attributs du produit: The 429 antibody reacts with both the long (~110 kDa) transmembrane-spanning form and the truncated (~47 kDa) GPI-linked form of vascular cell adhesion molecule-1 (VCAM-1, CD106). CD106 is constitutively expressed on bone marrow stromal cells, myeloid cells, and splenic dendritic cells. Its expression on endothelial cells is upregulated by inflammatory cytokines and in certain pathologic conditions. CD106 expression has also been detected on apoptotic thymocytes, splenocytes, and lymphoid cell lines. VCAM-1 is a counter-receptor for VLA-4 (α4β1 integrin) and LPAM-1 (α4β7 integrin), and the 429 antibody partially blocks VCAM-1-mediated binding functions. Source of the immunogen was mouse preadipose cell line PA6.

BD Pharmingen™ Purified Rat Anti-Mouse CD106 - Purified - Clone 429 (MVCAM.A) - Isotype Rat IgG2a, κ - Reactivity Ms - 0.5 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse preadipose cell line PA6

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-VCAM1 (ABIN2688881)

Koni, Joshi, Temann, Olson, Burkly, Flavell: "Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow." dans: The Journal of experimental medicine, Vol. 193, Issue 6, pp. 741-54, (2001) (PubMed).

Ishiyama, Kitagawa, Takahashi, Kina, Hirokawa: "Expression of VCAM-1 in lymphocytes during the process of apoptosis." dans: Pathobiology : journal of immunopathology, molecular and cellular biology, Vol. 66, Issue 6, pp. 274-83, (1998) (PubMed).

Buck, Edelman, Buck, Kennedy, Baldwin: "Expression patterns of adhesion receptors in the developing mouse lung: functional implications." dans: Cell adhesion and communication, Vol. 4, Issue 2, pp. 69-87, (1997) (PubMed).

Kinashi, Springer: "Adhesion molecules in hematopoietic cells." dans: Blood cells, Vol. 20, Issue 1, pp. 25-44, (1995) (PubMed).

Kinashi, St Pierre, Springer: "Expression of glycophosphatidylinositol-anchored and -non-anchored isoforms of vascular cell adhesion molecule 1 in murine stromal and endothelial cells." dans: Journal of leukocyte biology, Vol. 57, Issue 1, pp. 168-73, (1995) (PubMed).

Baron, Reich, Visintin, Janeway: "The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1." dans: The Journal of clinical investigation, Vol. 93, Issue 4, pp. 1700-8, (1994) (PubMed).

Bevilacqua: "Endothelial-leukocyte adhesion molecules." dans: Annual review of immunology, Vol. 11, Issue 4, pp. 767-804, (1993) (PubMed).

Détails sur VCAM1

Antigène: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Autre désignation: CD106

Sujet: Synonyms: VCAM-1

Pathways: Carbohydrate Homeostasis